結構式
CAS: 16029-98-4
分子式: C3H9ISi
分子量: 200.09
中文名稱: 三甲基碘硅烷
碘代三甲硅烷
三甲基硅基化碘
英文名稱: Trimethylsilyl iodide
iodotrimethyl-silane
iodotrimethylsilane
trimethyliodosilane
trimethyliodosilane(tmis)
iodo-trimethyl-silane
性質描述: 可燃液體。沸點106-108℃，相對密度（20/4℃）1.41。
用途: 主要用于脫烷基化及相關反應中的一種高效試劑，可作為一些活性基團（氨基、羥基）的保護劑，可用于頭孢的合成。
使用注意:儲存中易變紅（主要是分解出單質碘），因此在儲存中加入銅粉。在空氣中易發煙，且使溶液發紅（原因 與水反應）.
其它信息：
Material Safety Data Sheet
Iodotrimethylsilane, 99% (stabilized over copper)
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Section 1 - Chemical Product and Company Identification |
MSDS Name: Iodotrimethylsilane, 99% (stabilized over copper)
Synonyms: Trimethylsilyl iodide
Company Identification: ZheJiang JuHua cregent Co Ltd
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Section 2 - Composition, Information on Ingredients |
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CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
|
16029-98-4 |
IODOTRIMETHYLSILANE |
99% |
240-171-0 |
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Section 3 - Hazards Identification |
EMERGENCY OVERVIEW
Appearance: clear very slight brown liquid. Flash Point: -31 deg C.
Danger! Water-reactive. Causes eye and skin burns. Causes digestive and respiratory tract burns. Flammable liquid and vapor.
Target Organs: None known.
Potential Health Effects
Eye: Causes eye burns.
Skin: Causes skin burns.
Ingestion: Causes gastrointestinal tract burns.
Inhalation: Causes chemical burns to the respiratory tract. Aspiration may cause respiratory swelling and pneumonitis.
Chronic: Not available. None
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Section 4 - First Aid Measures |
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures |
General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Flammable liquid and vapor. Reacts with water to form explosive hydrogen gas.
Extinguishing Media: Use carbon dioxide or dry chemical. DO NOT USE WATER!
Flash Point: -31 deg C ( -23.80 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower: Not available.
Upper: Not available.
NFPA Rating: Not published.
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Section 6 - Accidental Release Measures |
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool.
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Section 7 - Handling and Storage |
Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances.
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Section 8 - Exposure Controls, Personal Protection |
Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
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Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
|
IODOTRIMETHYLSILANE |
none listed |
6 mg/m3 TWA (listed under Silica, amorphous).3000 mg/m3 IDLH (listed under Silica, amorphous). |
none listed |
OSHA Vacated PELs: IODOTRIMETHYLSILANE: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties |
Physical State: Liquid
Appearance: clear very slight brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: 106 deg C @ 760.00mm Hg
Freezing/Melting Point: Not available.
Decomposition Temperature: Not available.
Solubility: reacts
Specific Gravity/Density:1.4060g/cm3
Molecular Formula: C3H9ISi
Molecular Weight: 200.10
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Section 10 - Stability and Reactivity |
Chemical Stability: Not available.
Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, strong bases, reacts violently with water..
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, silicon dioxide, hydrogen iodide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information |
RTECS#:
CAS# 16029-98-4 unlisted.
LD50/LC50: Not available.
Carcinogenicity:
CAS# 16029-98-4: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No data available.
Teratogenicity: No data available.
Reproductive Effects: No data available.
Mutagenicity: No data available.
Neurotoxicity: No data available.
Other Studies:
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Section 12 - Ecological Information |
No information available.
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Section 13 - Disposal Considerations |
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information |
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US DOT |
Canada TDG |
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Shipping Name: |
FLAMMABLE LIQUIDS, CORROSIVE, N.O.S. |
FLAMMABLE LIQUID CORROSIVE NOS (IODOTRIMETHYLSILANE) |
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Hazard Class: |
3 |
3(8) |
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UN Number: |
UN2924 |
UN2924 |
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Packing Group: |
II |
II |
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Section 15 - Regulatory Information |
US FEDERAL
TSCA
CAS# 16029-98-4 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313 No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA.
None of the chemicals in this product are listed as Priority Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 16029-98-4 can be found on the following state right to know lists: California, (listed as Silica, amorphous), New Jersey, (listed as Silica, amorphous), Pennsylvania, (listed as Silica, amorphous), Minnesota, (listed as Silica, amorphous), Massachusetts, (listed as Silica, amorphous).
California Prop 65
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
F C
Risk Phrases:
R 11 Highly flammable.
R 34 Causes burns.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 25 Avoid contact with eyes.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 16029-98-4: 1
Canada - DSL/NDSL
CAS# 16029-98-4 is listed on Canada's NDSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, E, F.
Canadian Ingredient Disclosure List
CAS# 16029-98-4 (listed as Silica, amorphous) is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information |
MSDS Creation Date: 12/12/2003
